In 2019, Ghana confirmed an outbreak of poliovirus type 2 (VDPV2) in eleven regions, necessitating an urgent vaccination campaign. This effort was challenged by the COVID-19 pandemic, which also resulted in decreased vitamin A supplementation coverage in the country. There was a need to integrate these two campaigns to address both the polio outbreak and support ongoing nutrition interventions during the pandemic. This study documented the experiences and lessons learned throughout the integration process.