COVAX, the vaccine pillar of the ACT Accelerator, is co-led by CEPI, Gavi, UNICEF, and WHO, and will facilitate the equitable The ease in reaching health services or health facilities in terms of location, time, and ease of approach. and distribution of vaccines to protect people in all countries through the values framework endorsed by the WHO SAGE on immunization. As countries, through their Interagency Coordinating Committee (ICC) and their logistics advisory sub-groups (the NLWG) are preparing their National Deployment and Vaccination Plans (NDVP) for COVID-19 vaccines and preparing funding proposals to Gavi, Global Fund, the World Bank and other donors, there is an opportunity to identify areas where digital solutions and innovations can amplify the efforts, while producing actionable data. As per the Gavi CDS guidelines (pg 6), countries are encouraged to include innovative activities that support COVID-19 vaccine delivery in their CDS needs based funding requests where possible. For the CDS needs based funding requests, Gavi defines innovation broadly, as the use of practices, products, or services new to COVID19 vaccine delivery in a country. In this guide, we have provided an overview of the most evidence based and promising digital innovations and procedures that can be deployed at different times during vaccine planning, distribution and scale in low- and middle-income settings, using the NDVP framework. The proposed actions presented complement broader guidance and make strategic references to the WHO Digital Implementation aims to develop strategies for available or new health interventions in order to improve access to, and the use of, these Investment guide (DIIG), and the UNICEF digital health guidance for COVID-19 response.