Located in the ‘meningitis belt’ of West Africa, Guinea experiences recurring epidemics of meningitis A and measles. These diseases overlap in high-risk areas, and children aged 13 to 24 months are targeted for vaccination with both MenAfrivac (MenA) and MEAS2. However, in 2021, vaccination campaigns for these diseases were postponed due to the COVID-19 pandemic and epidemics of Ebola, Marburg, Lassa, and yellow fever. This presented an opportunity for exploring campaign integration to increase efficiency and effectiveness of campaigns in delivering lifesaving interventions to the population. Guinea’s Expanded Program of Immunization (EPI) sought to prevent recurrent and seasonal epidemics of meningitis and measles by using a single, integrated campaign to reach the same target population.